Importance of miRNA stability and alternative primary miRNA isoforms in gene regulation during Drosophila development

• Main Authors: Zhou, Li, Lim, Mandy Yu Theng, Kaur, Prameet, Saj, Abil, Bortolamiol-Becet, Diane, Gopal, Vikneswaran, Tolwinski, Nicholas, Tucker-Kellogg, Greg, Okamura, Katsutomo
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: DRNTU::Science::Biological sciences; Pri-miRNAs; Gene Regulation
• Online Access: https://hdl.handle.net/10356/88981; http://hdl.handle.net/10220/46032
• Institution: Nanyang Technological University

Mature microRNAs (miRNAs) are processed from primary transcripts (pri-miRNAs), and their expression is controlled at transcriptional and post-transcriptional levels. However, how regulation at multiple levels achieves precise control remains elusive. Using published and new datasets, we profile a ti...