Antiviral cystine knot α-amylase inhibitors from alstonia scholaris

• Main Authors: Nguyen, Phuong Quoc Thuc, Ooi, Justin Seng Geap, Nguyen, Ngan Thi Kim, Wang, Shujing, Huang, Mei, Liu, Ding Xiang, Tam, James P.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Antiviral Agent; Cysteine-mediated Cross-linking; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/88984; http://hdl.handle.net/10220/46053
• Institution: Nanyang Technological University

Cystine knot α-amylase inhibitors are cysteine-rich, proline-rich peptides found in the Amaranthaceae and Apocynaceae plant species. They are characterized by a pseudocyclic backbone with two to four prolines and three disulfides arranged in a knotted motif. Similar to other knottins, cystine knot α...