Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity

Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity

Ruthenium compounds have become promising alternatives to platinum drugs by displaying specific activities against different cancers and favourable toxicity and clearance properties. Nonetheless, their molecular targeting and mechanism of action are poorly understood. Here we study two prototypical...

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Bibliographic Details
Main Authors: Davey, Curt Alexander, Adhireksan, Zenita, Davey, Gabriela E., Campomanes, Pablo, Groessl, Michael, Clavel, Catherine M., Yu, Haojie, Nazarov, Alexey A., Yeo, Charmian Hui Fang, Ang, Wee Han, Dröge, Peter, Rothlisberger, Ursula, Dyson, Paul J.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2018
Subjects:
DRNTU::Science::Biological sciences
Chemical Biology
Chemotherapy
Online Access:https://hdl.handle.net/10356/89056
http://hdl.handle.net/10220/46092
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/89056
http://hdl.handle.net/10220/46092

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