Chromosomal instability-induced senescence potentiates cell non-autonomous tumourigenic effects

• Main Authors: He, Qianqian, Au, Bijin, Kulkarni, Madhura, Shen, Yang, Lim, Kah. J., Maimaiti, Jiamila, Wong, Cheng. Kit., Luijten, Monique Nicole Helena, Chong, Han Chung, Lim, Elaine H., Rancati, Giulia, Sinha, Indrajit, Fu, Zhiyan, Wang, Xiaomeng, Connolly, John. E., Crasta, Karen Carmelina
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Cellular Migration; DRNTU::Science::Medicine; SAC
• Online Access: https://hdl.handle.net/10356/89120; http://hdl.handle.net/10220/46078
• Institution: Nanyang Technological University

Chromosomal instability (CIN), a high rate of chromosome loss or gain, is often associated with poor prognosis and drug resistance in cancers. Aneuploid, including near-polyploid, cells contain an abnormal number of chromosomes and exhibit CIN. The post-mitotic cell fates following generation of dif...