Chromosomal instability-induced senescence potentiates cell non-autonomous tumourigenic effects

• Main Authors: He, Qianqian, Au, Bijin, Kulkarni, Madhura, Shen, Yang, Lim, Kah. J., Maimaiti, Jiamila, Wong, Cheng. Kit., Luijten, Monique Nicole Helena, Chong, Han Chung, Lim, Elaine H., Rancati, Giulia, Sinha, Indrajit, Fu, Zhiyan, Wang, Xiaomeng, Connolly, John. E., Crasta, Karen Carmelina
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2018
• 主題: Cellular Migration; DRNTU::Science::Medicine; SAC
• 在線閱讀: https://hdl.handle.net/10356/89120; http://hdl.handle.net/10220/46078

Chromosomal instability (CIN), a high rate of chromosome loss or gain, is often associated with poor prognosis and drug resistance in cancers. Aneuploid, including near-polyploid, cells contain an abnormal number of chromosomes and exhibit CIN. The post-mitotic cell fates following generation of dif...