Inertial-based filtration method for removal of microcarriers from mesenchymal stem cell suspensions

• Main Authors: Moloudi, Reza, Oh, Steve, Yang, Chun, Teo, Kim Leng, Lam, Alan Tin-Lun, Warkiani, Majid Ebrahimi, Naing, May Win
• Other Authors: School of Mechanical and Aerospace Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: Microcarriers; Mesenchymal Stem Cell; DRNTU::Engineering::Bioengineering
• Online Access: https://hdl.handle.net/10356/89128; http://hdl.handle.net/10220/46116
• Institution: Nanyang Technological University

Rapidly evolving cell-based therapies towards clinical trials demand alternative approaches for efficient expansion of adherent cell types such as human mesenchymal stem cells (hMSCs). Using microcarriers (100–300 µm) in a stirred tank bioreactor offers considerably enhanced surface to volume ratio...