Multiple aperture synthetic optical coherence tomography for biological tissue imaging

An inherent compromise must be made between transverse resolution and depth of focus (DOF) in spectral domain optical coherence tomography (SD-OCT). Thus far, OCT has not been capable of providing a sufficient DOF to stably acquire cellular-resolution images. We previously reported a novel technique...

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Main Authors: Bo, En, Ge, Xin, Wang, Lulu, Wu, Xuan, Luo, Yuemei, Chen, Shufen, Chen, Si, Liang, Haitao, Ni, Guangming, Yu, Xiaojun, Liu, Linbo
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2018
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Online Access:https://hdl.handle.net/10356/89188
http://hdl.handle.net/10220/44808
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-891882020-03-07T14:02:36Z Multiple aperture synthetic optical coherence tomography for biological tissue imaging Bo, En Ge, Xin Wang, Lulu Wu, Xuan Luo, Yuemei Chen, Shufen Chen, Si Liang, Haitao Ni, Guangming Yu, Xiaojun Liu, Linbo School of Chemical and Biomedical Engineering School of Electrical and Electronic Engineering Medical And Biological Imaging Optical Coherence Tomography An inherent compromise must be made between transverse resolution and depth of focus (DOF) in spectral domain optical coherence tomography (SD-OCT). Thus far, OCT has not been capable of providing a sufficient DOF to stably acquire cellular-resolution images. We previously reported a novel technique named multiple aperture synthesis (MAS) to extend the DOF in high-resolution OCT [Optica 4, 701 (2017)]. In this technique, the illumination beam is scanned across the objective lens pupil plane by being steered at the pinhole using a custom-made microcylindrical lens. Images captured via multiple distinctive apertures were digitally refocused, which is similar to synthetic aperture radar. In this study, we applied this technique for the first time to image both a homemade microparticle sample and biological tissue. The results demonstrated the feasibility and efficacy of high-resolution biological tissue imaging with a dramatic DOF extension. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) NMRC (Natl Medical Research Council, S’pore) Published version 2018-05-16T07:42:48Z 2019-12-06T17:19:48Z 2018-05-16T07:42:48Z 2019-12-06T17:19:48Z 2018 Journal Article Bo, E., Ge, X., Wang, L., Wu, X., Luo, Y., Chen, S., et al. (2018). Multiple aperture synthetic optical coherence tomography for biological tissue imaging. Optics Express, 26(2), 772-780. https://hdl.handle.net/10356/89188 http://hdl.handle.net/10220/44808 10.1364/OE.26.000772 en Optics Express © 2018 Optical Society of America. This paper was published in Optics Express and is made available as an electronic reprint (preprint) with permission of Optical Society of America. The published version is available at: [http://dx.doi.org/10.1364/OE.26.000772]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 9 p. application/pdf
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Medical And Biological Imaging
Optical Coherence Tomography
spellingShingle Medical And Biological Imaging
Optical Coherence Tomography
Bo, En
Ge, Xin
Wang, Lulu
Wu, Xuan
Luo, Yuemei
Chen, Shufen
Chen, Si
Liang, Haitao
Ni, Guangming
Yu, Xiaojun
Liu, Linbo
Multiple aperture synthetic optical coherence tomography for biological tissue imaging
description An inherent compromise must be made between transverse resolution and depth of focus (DOF) in spectral domain optical coherence tomography (SD-OCT). Thus far, OCT has not been capable of providing a sufficient DOF to stably acquire cellular-resolution images. We previously reported a novel technique named multiple aperture synthesis (MAS) to extend the DOF in high-resolution OCT [Optica 4, 701 (2017)]. In this technique, the illumination beam is scanned across the objective lens pupil plane by being steered at the pinhole using a custom-made microcylindrical lens. Images captured via multiple distinctive apertures were digitally refocused, which is similar to synthetic aperture radar. In this study, we applied this technique for the first time to image both a homemade microparticle sample and biological tissue. The results demonstrated the feasibility and efficacy of high-resolution biological tissue imaging with a dramatic DOF extension.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Bo, En
Ge, Xin
Wang, Lulu
Wu, Xuan
Luo, Yuemei
Chen, Shufen
Chen, Si
Liang, Haitao
Ni, Guangming
Yu, Xiaojun
Liu, Linbo
format Article
author Bo, En
Ge, Xin
Wang, Lulu
Wu, Xuan
Luo, Yuemei
Chen, Shufen
Chen, Si
Liang, Haitao
Ni, Guangming
Yu, Xiaojun
Liu, Linbo
author_sort Bo, En
title Multiple aperture synthetic optical coherence tomography for biological tissue imaging
title_short Multiple aperture synthetic optical coherence tomography for biological tissue imaging
title_full Multiple aperture synthetic optical coherence tomography for biological tissue imaging
title_fullStr Multiple aperture synthetic optical coherence tomography for biological tissue imaging
title_full_unstemmed Multiple aperture synthetic optical coherence tomography for biological tissue imaging
title_sort multiple aperture synthetic optical coherence tomography for biological tissue imaging
publishDate 2018
url https://hdl.handle.net/10356/89188
http://hdl.handle.net/10220/44808
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