Drug-target interaction prediction via class imbalance-aware ensemble learning

• Main Authors: Ezzat, Ali, Wu, Min, Li, Xiao-Li, Kwoh, Chee-Keong
• Other Authors: School of Computer Science and Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: Drug-target Interaction Prediction; Class Imbalance; DRNTU::Engineering::Computer science and engineering
• Online Access: https://hdl.handle.net/10356/89292; http://hdl.handle.net/10220/46173
• Institution: Nanyang Technological University

Background: Multiple computational methods for predicting drug-target interactions have been developed to facilitate the drug discovery process. These methods use available data on known drug-target interactions to train classifiers with the purpose of predicting new undiscovered interactions. Howev...