Acquisition and loss of virulence-associated factors during genome evolution and speciation in three clades of Bordetella species

• Main Authors: Linz, Bodo, Ivanov, Yury V., Preston, Andrew, Brinkac, Lauren, Parkhill, Julian, Kim, Maria, Harris, Simon R., Goodfield, Laura L., Fry, Norman K., Gorringe, Andrew R., Nicholson, Tracy L., Register, Karen B., Losada, Liliana, Harvill, Eric T.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: DRNTU::Science::Medicine; Bordetella; Evolution
• Online Access: https://hdl.handle.net/10356/89293; http://hdl.handle.net/10220/46171
• Institution: Nanyang Technological University

Background: The genus Bordetella consists of nine species that include important respiratory pathogens such as the ‘classical’ species B. bronchiseptica, B. pertussis and B. parapertussis and six more distantly related and less extensively studied species. Here we analyze sequence diversity and gene...