IgG1 memory B cells keep the memory of IgE responses

• Main Authors: Zolezzi, Francesca, He, Jin-Shu, Subramaniam, Sharrada, Narang, Vipin, Srinivasan, Kandhadayar, Saunders, Sean P., Carbajo, Daniel, Wen-Shan, Tsao, Hidayah Hamadee, Nur, Lum, Josephine, Lee, Andrea, Chen, Jinmiao, Poidinger, Michael, Lafaille, Juan J., Curotto de Lafaille, Maria A.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Flow Cytometry; Microarray Analysis
• Online Access: https://hdl.handle.net/10356/89520; http://hdl.handle.net/10220/44962
• Institution: Nanyang Technological University

The unique differentiation of IgE cells suggests unconventional mechanisms of IgE memory. IgE germinal centre cells are transient, most IgE cells are plasma cells, and high affinity IgE is produced by the switching of IgG1 cells to IgE. Here we investigate the function of subsets of IgG1 memory B ce...