Crystallographic studies of chromatin-targeting metal-based compounds and nucleosome core particles assembled with engineered cohesive end DNA fragments

In eukaryotic cells, related functions like the storage, protection, and precise regulation of genomic DNA are achieved by its compaction into protein–nucleic acid complex structures known as chromosomes. During the initial steps of compaction, naked DNA is wound around an octamer of histone protein...

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Bibliographic Details
Main Author: Louis, DeFalco Jr.
Other Authors: Curtis Alexander Davey
Format: Theses and Dissertations
Language:English
Published: 2019
Subjects:
Online Access:https://hdl.handle.net/10356/89610
http://hdl.handle.net/10220/47720
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Institution: Nanyang Technological University
Language: English