Biocompatible hydroxylated boron nitride nanosheets/poly(vinyl alcohol) interpenetrating hydrogels with enhanced mechanical and thermal responses

Poly(vinyl alcohol) (PVA) hydrogels with tissue-like viscoelasticity, excellent biocompatibility, and high hydrophilicity have been considered as promising cartilage replacement materials. However, lack of sufficient mechanical properties is a critical barrier to their use as load-bearing cartilage...

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Main Authors: Jing, Lin, Li, Hongling, Tay, Roland Yingjie, Sun, Bo, Tsang, Siu Hon, Cometto, Olivier, Lin, Jinjun, Teo, Edwin Hang Tong, Tok, Alfred Iing Yoong
Other Authors: School of Electrical and Electronic Engineering
Format: Article
Language:English
Published: 2018
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Online Access:https://hdl.handle.net/10356/89613
http://hdl.handle.net/10220/44997
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-896132020-06-01T10:01:35Z Biocompatible hydroxylated boron nitride nanosheets/poly(vinyl alcohol) interpenetrating hydrogels with enhanced mechanical and thermal responses Jing, Lin Li, Hongling Tay, Roland Yingjie Sun, Bo Tsang, Siu Hon Cometto, Olivier Lin, Jinjun Teo, Edwin Hang Tong Tok, Alfred Iing Yoong School of Electrical and Electronic Engineering School of Materials Science & Engineering Institute for Sports Research Temasek Laboratories Boron Nitride Nanosheets Cytocompatibility Poly(vinyl alcohol) (PVA) hydrogels with tissue-like viscoelasticity, excellent biocompatibility, and high hydrophilicity have been considered as promising cartilage replacement materials. However, lack of sufficient mechanical properties is a critical barrier to their use as load-bearing cartilage substitutes. Herein, we report hydroxylated boron nitride nanosheets (OH-BNNS)/PVA interpenetrating hydrogels by cyclically freezing/thawing the aqueous mixture of PVA and highly hydrophilic OH-BNNS (up to 0.6 mg/mL, two times the highest reported so far). Encouragingly, the resulting OH-BNNS/PVA hydrogels exhibit controllable reinforcements in both mechanical and thermal responses by simply varying the OH-BNNS contents. Impressive 45, 43, and 63% increases in compressive, tensile strengths and Young’s modulus, respectively, can be obtained even with only 0.12 wt% (OH-BNNS:PVA) OH-BNNS addition. Meanwhile, exciting improvements in the thermal diffusivity (15%) and conductivity (5%) can also be successfully achieved. These enhancements are attributed to the synergistic effect of intrinsic superior properties of the as-prepared OH-BNNS and strong hydrogen bonding interactions between the OH-BNNS and PVA chains. In addition, excellent cytocompatibility of the composite hydrogels was verified by cell proliferation and live/dead viability assays. These biocompatible OH-BNNS/PVA hydrogels are promising in addressing the mechanical failure and locally overheating issues as cartilage substitutes and may also have broad utility for biomedical applications, such as drug delivery, tissue engineering, biosensors, and actuators. MOE (Min. of Education, S’pore) 2018-06-08T03:38:04Z 2019-12-06T17:29:35Z 2018-06-08T03:38:04Z 2019-12-06T17:29:35Z 2017 Journal Article Jing, L., Li, H., Tay, R. Y., Sun, B., Tsang, S. H., Cometto, O., et al. (2017). Biocompatible Hydroxylated Boron Nitride Nanosheets/Poly(vinyl alcohol) Interpenetrating Hydrogels with Enhanced Mechanical and Thermal Responses. ACS Nano, 11(4), 3742-3751. 1936-0851 https://hdl.handle.net/10356/89613 http://hdl.handle.net/10220/44997 10.1021/acsnano.6b08408 en ACS Nano © 2017 American Chemical Society
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Boron Nitride Nanosheets
Cytocompatibility
spellingShingle Boron Nitride Nanosheets
Cytocompatibility
Jing, Lin
Li, Hongling
Tay, Roland Yingjie
Sun, Bo
Tsang, Siu Hon
Cometto, Olivier
Lin, Jinjun
Teo, Edwin Hang Tong
Tok, Alfred Iing Yoong
Biocompatible hydroxylated boron nitride nanosheets/poly(vinyl alcohol) interpenetrating hydrogels with enhanced mechanical and thermal responses
description Poly(vinyl alcohol) (PVA) hydrogels with tissue-like viscoelasticity, excellent biocompatibility, and high hydrophilicity have been considered as promising cartilage replacement materials. However, lack of sufficient mechanical properties is a critical barrier to their use as load-bearing cartilage substitutes. Herein, we report hydroxylated boron nitride nanosheets (OH-BNNS)/PVA interpenetrating hydrogels by cyclically freezing/thawing the aqueous mixture of PVA and highly hydrophilic OH-BNNS (up to 0.6 mg/mL, two times the highest reported so far). Encouragingly, the resulting OH-BNNS/PVA hydrogels exhibit controllable reinforcements in both mechanical and thermal responses by simply varying the OH-BNNS contents. Impressive 45, 43, and 63% increases in compressive, tensile strengths and Young’s modulus, respectively, can be obtained even with only 0.12 wt% (OH-BNNS:PVA) OH-BNNS addition. Meanwhile, exciting improvements in the thermal diffusivity (15%) and conductivity (5%) can also be successfully achieved. These enhancements are attributed to the synergistic effect of intrinsic superior properties of the as-prepared OH-BNNS and strong hydrogen bonding interactions between the OH-BNNS and PVA chains. In addition, excellent cytocompatibility of the composite hydrogels was verified by cell proliferation and live/dead viability assays. These biocompatible OH-BNNS/PVA hydrogels are promising in addressing the mechanical failure and locally overheating issues as cartilage substitutes and may also have broad utility for biomedical applications, such as drug delivery, tissue engineering, biosensors, and actuators.
author2 School of Electrical and Electronic Engineering
author_facet School of Electrical and Electronic Engineering
Jing, Lin
Li, Hongling
Tay, Roland Yingjie
Sun, Bo
Tsang, Siu Hon
Cometto, Olivier
Lin, Jinjun
Teo, Edwin Hang Tong
Tok, Alfred Iing Yoong
format Article
author Jing, Lin
Li, Hongling
Tay, Roland Yingjie
Sun, Bo
Tsang, Siu Hon
Cometto, Olivier
Lin, Jinjun
Teo, Edwin Hang Tong
Tok, Alfred Iing Yoong
author_sort Jing, Lin
title Biocompatible hydroxylated boron nitride nanosheets/poly(vinyl alcohol) interpenetrating hydrogels with enhanced mechanical and thermal responses
title_short Biocompatible hydroxylated boron nitride nanosheets/poly(vinyl alcohol) interpenetrating hydrogels with enhanced mechanical and thermal responses
title_full Biocompatible hydroxylated boron nitride nanosheets/poly(vinyl alcohol) interpenetrating hydrogels with enhanced mechanical and thermal responses
title_fullStr Biocompatible hydroxylated boron nitride nanosheets/poly(vinyl alcohol) interpenetrating hydrogels with enhanced mechanical and thermal responses
title_full_unstemmed Biocompatible hydroxylated boron nitride nanosheets/poly(vinyl alcohol) interpenetrating hydrogels with enhanced mechanical and thermal responses
title_sort biocompatible hydroxylated boron nitride nanosheets/poly(vinyl alcohol) interpenetrating hydrogels with enhanced mechanical and thermal responses
publishDate 2018
url https://hdl.handle.net/10356/89613
http://hdl.handle.net/10220/44997
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