Thermostable exoshells fold and stabilize recombinant proteins

• Main Authors: Deshpande, Siddharth, Masurkar, Nihar D., Girish, Vallerinteavide Mavelli, Desai, Malan, Chakraborty, Goutam, Chan, Juliana M., Drum, Chester L.
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: Nanoparticles; Protein Folding
• Online Access: https://hdl.handle.net/10356/89629; http://hdl.handle.net/10220/44987
• Institution: Nanyang Technological University

The expression and stabilization of recombinant proteins is fundamental to basic and applied biology. Here we have engineered a thermostable protein nanoparticle (tES) to improve both expression and stabilization of recombinant proteins using this technology. tES provides steric accommodation and ch...