Intracerebral haemorrhage in down syndrome: protected or predisposed?

• Main Authors: Buss, Lewis, Fisher, Elizabeth, Hardy, John, Nizetic, Dean, Groet, Jurgen, Pulford, Laura, Strydom, André
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Intracerebral Haemorrhage; Down Syndrome; DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/89657; http://hdl.handle.net/10220/47106
• Institution: Nanyang Technological University

Down syndrome (DS), which arises from trisomy of chromosome 21, is associated with deposition of large amounts of amyloid within the central nervous system. Amyloid accumulates in two compartments: as plaques within the brain parenchyma and in vessel walls of the cerebral microvasculature. The paren...