Intracerebral haemorrhage in down syndrome: protected or predisposed?

• المؤلفون الرئيسيون: Buss, Lewis, Fisher, Elizabeth, Hardy, John, Nizetic, Dean, Groet, Jurgen, Pulford, Laura, Strydom, André
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2018
• الموضوعات: Intracerebral Haemorrhage; Down Syndrome; DRNTU::Science::Medicine
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/89657; http://hdl.handle.net/10220/47106

Down syndrome (DS), which arises from trisomy of chromosome 21, is associated with deposition of large amounts of amyloid within the central nervous system. Amyloid accumulates in two compartments: as plaques within the brain parenchyma and in vessel walls of the cerebral microvasculature. The paren...