From Drosophila segmentation to human cancer therapy

• Main Author: Ingham, Philip William
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Drosophila; Embryos Mutant; DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/89811; http://hdl.handle.net/10220/47150
• Institution: Nanyang Technological University

First described in Drosophila, Hedgehog signalling is a key regulator of embryonic development and tissue homeostasis and its dysfunction underlies a variety of human congenital anomalies and diseases. Although now recognised as a major target for cancer therapy as well as a mediator of directed ste...