Evidence for allosteric effects on p53 oligomerization induced by phosphorylation

• Main Authors: Muller, Petr, Chan, Juliana M., Simoncik, Oliver, Fojta, Miroslav, Lane, David P., Hupp, Ted, Vojtesek, Borivoj
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Chemistry; Protein; Oligomerization
• Online Access: https://hdl.handle.net/10356/89905; http://hdl.handle.net/10220/47748
• Institution: Nanyang Technological University

p53 is a tetrameric protein with a thermodynamically unstable deoxyribonucleic acid (DNA)‐binding domain flanked by intrinsically disordered regulatory domains that control its activity. The unstable and disordered segments of p53 allow high flexibility as it interacts with binding partners and perm...