Small colony variants and single nucleotide variations in Pf1 region of PB1 phage-resistant pseudomonas aeruginosa

• Main Authors: Lim, Wee S., Phang, Kevin K. S., Tan, Andy Hee-Meng, Li, Sam F.-Y., Ow, Dave S.-W.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Phage Therapy; DRNTU::Science::Medicine; Pseudomonas Aeruginosa
• Online Access: https://hdl.handle.net/10356/89917; http://hdl.handle.net/10220/46413
• Institution: Nanyang Technological University

Phage therapy involves the application of lytic bacteriophages for treatment of clinical infections but bacterial resistance may develop over time. Isolated from nosocomial infections, small colony variants (SCVs) are morphologically distinct, highly virulent bacterial strains that are resistant to...