Long-term culture of human liver tissue with advanced hepatic functions

• Main Authors: Xiong, Anming, Ng, Soon Seng, Nguyen, Khanh, Masek, Marilyn, No, Da Yoon, Elazar, Menashe, Shteyer, Eyal, Winters, Mark A., Voedisch, Amy, Shaw, Kate, Rashid, Sheikh Tamir, Frank, Curtis W., Cho, Nam Joon, Glenn, Jeffrey S.
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: DRNTU::Engineering::Materials; Technical Advance; Gastroenterology
• Online Access: https://hdl.handle.net/10356/90007; http://hdl.handle.net/10220/47177
• Institution: Nanyang Technological University

A major challenge for studying authentic liver cell function and cell replacement therapies is that primary human hepatocytes rapidly lose their advanced function in conventional, 2-dimensional culture platforms. Here, we describe the fabrication of 3-dimensional hexagonally arrayed lobular human li...