POPX2 is a novel LATS phosphatase that regulates the Hippo pathway

• Main Authors: Muhammad Bakhait Rahmat, Zhang, Songjing, Koh, Cheng-Gee
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Science::Biological sciences; POPX2 Phosphatase; Hippo Pathway
• Online Access: https://hdl.handle.net/10356/90014; http://hdl.handle.net/10220/49377
• Institution: Nanyang Technological University

The Hippo pathway regulates cell proliferation, survival, apoptosis and differentiation. During carcinogenesis, members of the Hippo pathway are mutated to avoid anoikis and promote anchorage independent growth. Although many regulators of the Hippo pathway have been reported, negative regulators of...