A randomised controlled trial of a telephone administered brief HIV risk reduction intervention amongst men who have sex with men prescribed post-exposure prophylaxis for HIV after sexual exposure in the UK : project PEPSE

Background: In western countries, men who have sex with men (MSM) are most affected by HIV and increasingly likely to engage in risky sexual behaviour. MSM who experience a potential sexual exposure to HIV (PEPSE) and receive a preventative regimen of anti-HIV treatment are at particularly high risk...

Full description

Saved in:
Bibliographic Details
Main Authors: Llewellyn, Carrie Diane, Abraham, Charles, Pollard, Alex, Jones, Christopher Iain, Bremner, Stephen, Miners, Alec, Smith, Helen
Other Authors: Caylà, Joan A.
Format: Article
Language:English
Published: 2019
Subjects:
HIV
Online Access:https://hdl.handle.net/10356/90054
http://hdl.handle.net/10220/49390
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-90054
record_format dspace
spelling sg-ntu-dr.10356-900542020-11-01T05:18:49Z A randomised controlled trial of a telephone administered brief HIV risk reduction intervention amongst men who have sex with men prescribed post-exposure prophylaxis for HIV after sexual exposure in the UK : project PEPSE Llewellyn, Carrie Diane Abraham, Charles Pollard, Alex Jones, Christopher Iain Bremner, Stephen Miners, Alec Smith, Helen Caylà, Joan A. Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine HIV Human Sexual Behavior Background: In western countries, men who have sex with men (MSM) are most affected by HIV and increasingly likely to engage in risky sexual behaviour. MSM who experience a potential sexual exposure to HIV (PEPSE) and receive a preventative regimen of anti-HIV treatment are at particularly high risk of acquiring HIV and could potentially benefit from targeted risk reduction behavioural interventions such as motivational interviewing (MI). Purpose: The aim of this trial was to examine the impact of augmented MI (MI plus information provision and behavioural skills building), over and above routine care, on reducing risky sexual behaviour in MSM prescribed PEPSE. Secondary aims of the research were to examine whether the intervention reduced sexually transmitted infections (STI) and further requests for PEP. Methods: A parallel-group pragmatic randomised controlled trial was conducted with 175 MSM recruited from five sexual health (SH) clinics in the south east of England. The intervention was two fixed-duration sessions of telephone administered augmented MI. A manual guided the selection of individualised persuasive communication strategies based on underlying change mechanisms specified by the Information, Motivation and Behavioural Skills (IMB) model. Primary outcomes were the number of receptive and active anal intercourse (AI) partners, the use of condoms every time during receptive and active AI and the use of condoms sometimes during receptive and active AI. Results: There were no significant impacts on sexual risk behaviour or any of the psychological measures, and no discernible reduction in requests for repeat PEP or rates of STIs within a year. Conclusion: Our behavioural intervention of augmented MI did not affect risky sexual behaviour, rates of further PEP and STIs, and psychological factors, in MSM prescribed PEPSE. Published version 2019-07-17T01:47:08Z 2019-12-06T17:39:40Z 2019-07-17T01:47:08Z 2019-12-06T17:39:40Z 2019 Journal Article Llewellyn, C. D., Abraham, C., Pollard, A., Jones, C. I., Bremner, S., Miners, A., & Smith, H. (2019). A randomised controlled trial of a telephone administered brief HIV risk reduction intervention amongst men who have sex with men prescribed post-exposure prophylaxis for HIV after sexual exposure in the UK : project PEPSE. PLoS ONE, 14(5), e0216855-. doi:10.1371/journal.pone.0216855 https://hdl.handle.net/10356/90054 http://hdl.handle.net/10220/49390 10.1371/journal.pone.0216855 en PLoS ONE © 2019 Llewellyn et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 19 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Medicine
HIV
Human Sexual Behavior
spellingShingle Science::Medicine
HIV
Human Sexual Behavior
Llewellyn, Carrie Diane
Abraham, Charles
Pollard, Alex
Jones, Christopher Iain
Bremner, Stephen
Miners, Alec
Smith, Helen
A randomised controlled trial of a telephone administered brief HIV risk reduction intervention amongst men who have sex with men prescribed post-exposure prophylaxis for HIV after sexual exposure in the UK : project PEPSE
description Background: In western countries, men who have sex with men (MSM) are most affected by HIV and increasingly likely to engage in risky sexual behaviour. MSM who experience a potential sexual exposure to HIV (PEPSE) and receive a preventative regimen of anti-HIV treatment are at particularly high risk of acquiring HIV and could potentially benefit from targeted risk reduction behavioural interventions such as motivational interviewing (MI). Purpose: The aim of this trial was to examine the impact of augmented MI (MI plus information provision and behavioural skills building), over and above routine care, on reducing risky sexual behaviour in MSM prescribed PEPSE. Secondary aims of the research were to examine whether the intervention reduced sexually transmitted infections (STI) and further requests for PEP. Methods: A parallel-group pragmatic randomised controlled trial was conducted with 175 MSM recruited from five sexual health (SH) clinics in the south east of England. The intervention was two fixed-duration sessions of telephone administered augmented MI. A manual guided the selection of individualised persuasive communication strategies based on underlying change mechanisms specified by the Information, Motivation and Behavioural Skills (IMB) model. Primary outcomes were the number of receptive and active anal intercourse (AI) partners, the use of condoms every time during receptive and active AI and the use of condoms sometimes during receptive and active AI. Results: There were no significant impacts on sexual risk behaviour or any of the psychological measures, and no discernible reduction in requests for repeat PEP or rates of STIs within a year. Conclusion: Our behavioural intervention of augmented MI did not affect risky sexual behaviour, rates of further PEP and STIs, and psychological factors, in MSM prescribed PEPSE.
author2 Caylà, Joan A.
author_facet Caylà, Joan A.
Llewellyn, Carrie Diane
Abraham, Charles
Pollard, Alex
Jones, Christopher Iain
Bremner, Stephen
Miners, Alec
Smith, Helen
format Article
author Llewellyn, Carrie Diane
Abraham, Charles
Pollard, Alex
Jones, Christopher Iain
Bremner, Stephen
Miners, Alec
Smith, Helen
author_sort Llewellyn, Carrie Diane
title A randomised controlled trial of a telephone administered brief HIV risk reduction intervention amongst men who have sex with men prescribed post-exposure prophylaxis for HIV after sexual exposure in the UK : project PEPSE
title_short A randomised controlled trial of a telephone administered brief HIV risk reduction intervention amongst men who have sex with men prescribed post-exposure prophylaxis for HIV after sexual exposure in the UK : project PEPSE
title_full A randomised controlled trial of a telephone administered brief HIV risk reduction intervention amongst men who have sex with men prescribed post-exposure prophylaxis for HIV after sexual exposure in the UK : project PEPSE
title_fullStr A randomised controlled trial of a telephone administered brief HIV risk reduction intervention amongst men who have sex with men prescribed post-exposure prophylaxis for HIV after sexual exposure in the UK : project PEPSE
title_full_unstemmed A randomised controlled trial of a telephone administered brief HIV risk reduction intervention amongst men who have sex with men prescribed post-exposure prophylaxis for HIV after sexual exposure in the UK : project PEPSE
title_sort randomised controlled trial of a telephone administered brief hiv risk reduction intervention amongst men who have sex with men prescribed post-exposure prophylaxis for hiv after sexual exposure in the uk : project pepse
publishDate 2019
url https://hdl.handle.net/10356/90054
http://hdl.handle.net/10220/49390
_version_ 1683493566015340544