A two-step iteration mechanism for speckle reduction in optical coherence tomography

Optical coherence tomography (OCT) is an imaging tool that has been widely utilized for various disease diagnoses for its noninvasive and high-resolution properties. Due to the dual role of speckles in the imaging process, however, OCT images suffer from the unavoidable speckle noise, which is usual...

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Main Authors: Wang, Xianghong, Yu, Xiaojun, Liu, Xinyu, Chen, Si, Chen, Shufen, Wang, Nanshuo, Liu, Linbo
Other Authors: School of Electrical and Electronic Engineering
Format: Article
Language:English
Published: 2019
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Online Access:https://hdl.handle.net/10356/90101
http://hdl.handle.net/10220/48378
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-901012020-03-07T14:02:38Z A two-step iteration mechanism for speckle reduction in optical coherence tomography Wang, Xianghong Yu, Xiaojun Liu, Xinyu Chen, Si Chen, Shufen Wang, Nanshuo Liu, Linbo School of Electrical and Electronic Engineering Optical Coherence Tomography Image Processing DRNTU::Engineering::Electrical and electronic engineering Optical coherence tomography (OCT) is an imaging tool that has been widely utilized for various disease diagnoses for its noninvasive and high-resolution properties. Due to the dual role of speckles in the imaging process, however, OCT images suffer from the unavoidable speckle noise, which is usually regarded to be multiplicative in nature and reduces image contrast and resolution. In this study, we propose to categorize OCT speckle noise into additive portion and multiplicative portion, and present a simple two-step iteration (TSI) mechanism to suppress such noises separately. With the augmented Lagrange minimization (ALM) method adopted to recover a low-rank image, the first step of TSI is to remove the additive Gaussian noise, while the second step of TSI is to suppress the multiplicative noise by employing a split Bregman method (SBM) to solve the total-variation (TV) de-noising problem. Extensive experiments with OCT images of the swine eye, human and rabbit retina are conducted to verify the effectiveness of the proposed method. Results show that the proposed TSI method outperforms the existing methods in different cases. Specifically, TSI helps improve the peak signal-to-noise ratio (PSNR) and structure similarity (SSIM) of the swine eye images from 17.19 dB to 33 dB and 0.12 to 0.92, respectively, with the important structural details well preserved. The clearer boundaries and higher image contrast obtained with the TSI method would largely facilitate image analyses and interpretations for the clinical applications of OCT systems. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) NMRC (Natl Medical Research Council, S’pore) Accepted version 2019-05-27T05:54:27Z 2019-12-06T17:40:41Z 2019-05-27T05:54:27Z 2019-12-06T17:40:41Z 2018 Journal Article Wang, X., Yu, X., Liu, X., Chen, S., Chen, S., Wang, N., & Liu, L. (2018). A two-step iteration mechanism for speckle reduction in optical coherence tomography. Biomedical Signal Processing and Control, 43, 86-95. doi:10.1016/j.bspc.2018.02.011 1746-8094 https://hdl.handle.net/10356/90101 http://hdl.handle.net/10220/48378 10.1016/j.bspc.2018.02.011 en Biomedical Signal Processing and Control © 2018 Elsevier Ltd. All rights reserved. This paper was published in Biomedical Signal Processing and Control and is made available with permission of Elsevier Ltd. 23 p. application/pdf
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Optical Coherence Tomography
Image Processing
DRNTU::Engineering::Electrical and electronic engineering
spellingShingle Optical Coherence Tomography
Image Processing
DRNTU::Engineering::Electrical and electronic engineering
Wang, Xianghong
Yu, Xiaojun
Liu, Xinyu
Chen, Si
Chen, Shufen
Wang, Nanshuo
Liu, Linbo
A two-step iteration mechanism for speckle reduction in optical coherence tomography
description Optical coherence tomography (OCT) is an imaging tool that has been widely utilized for various disease diagnoses for its noninvasive and high-resolution properties. Due to the dual role of speckles in the imaging process, however, OCT images suffer from the unavoidable speckle noise, which is usually regarded to be multiplicative in nature and reduces image contrast and resolution. In this study, we propose to categorize OCT speckle noise into additive portion and multiplicative portion, and present a simple two-step iteration (TSI) mechanism to suppress such noises separately. With the augmented Lagrange minimization (ALM) method adopted to recover a low-rank image, the first step of TSI is to remove the additive Gaussian noise, while the second step of TSI is to suppress the multiplicative noise by employing a split Bregman method (SBM) to solve the total-variation (TV) de-noising problem. Extensive experiments with OCT images of the swine eye, human and rabbit retina are conducted to verify the effectiveness of the proposed method. Results show that the proposed TSI method outperforms the existing methods in different cases. Specifically, TSI helps improve the peak signal-to-noise ratio (PSNR) and structure similarity (SSIM) of the swine eye images from 17.19 dB to 33 dB and 0.12 to 0.92, respectively, with the important structural details well preserved. The clearer boundaries and higher image contrast obtained with the TSI method would largely facilitate image analyses and interpretations for the clinical applications of OCT systems.
author2 School of Electrical and Electronic Engineering
author_facet School of Electrical and Electronic Engineering
Wang, Xianghong
Yu, Xiaojun
Liu, Xinyu
Chen, Si
Chen, Shufen
Wang, Nanshuo
Liu, Linbo
format Article
author Wang, Xianghong
Yu, Xiaojun
Liu, Xinyu
Chen, Si
Chen, Shufen
Wang, Nanshuo
Liu, Linbo
author_sort Wang, Xianghong
title A two-step iteration mechanism for speckle reduction in optical coherence tomography
title_short A two-step iteration mechanism for speckle reduction in optical coherence tomography
title_full A two-step iteration mechanism for speckle reduction in optical coherence tomography
title_fullStr A two-step iteration mechanism for speckle reduction in optical coherence tomography
title_full_unstemmed A two-step iteration mechanism for speckle reduction in optical coherence tomography
title_sort two-step iteration mechanism for speckle reduction in optical coherence tomography
publishDate 2019
url https://hdl.handle.net/10356/90101
http://hdl.handle.net/10220/48378
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