The first intermolecular interrupted imino-Nazarov reaction: expeditious access to carbocyclic nucleoside analogues

• Main Authors: William, Ronny, Leng, Wei Lin, Wang, Siming, Liu, Xue-Wei
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Carbocyclic Nucleosides; Nazarov Reaction; DRNTU::Science::Physics
• Online Access: https://hdl.handle.net/10356/90209; http://hdl.handle.net/10220/47208
• Institution: Nanyang Technological University

The analogous imino-variant of the Nazarov reaction suffers from unfavorable energetics associated with the ring closure process, thereby limiting the utility of this class of reactions. In this report, the realization of the first intermolecular interrupted imino-Nazarov reaction utilizing silylated pyrimidine derivatives as nucleophilic trapping partners culminated in an expedient synthetic route to carbocyclic nucleoside analogues. The potential application of silylated nucleobases to intercept the oxyallyl cation in other variants of the Nazarov reaction provides vast opportunities to develop new strategies for the formation of carbocyclic nucleoside analogues.