Nanofibrous PLGA electrospun scaffolds modified with type I collagen influence hepatocyte function and support viability in vitro

• Main Authors: Brown, Jessica H., Das, Prativa, DiVito, Michael D., Ivancic, David, Tan, Lay Poh, Wertheim, Jason A.
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: Tissue Engineering; Electrospun Nanofibers; DRNTU::Engineering::Materials
• Online Access: https://hdl.handle.net/10356/90298; http://hdl.handle.net/10220/48478
• Institution: Nanyang Technological University

A major challenge of maintaining primary hepatocytes in vitro is progressive loss of hepatocyte-specific functions, such as protein synthesis and cytochrome P450 (CYP450) catalytic activity. We developed a three-dimensional (3D) nanofibrous scaffold made from poly(l-lactide-co-glycolide) (PLGA) poly...