Improved bioavailability of levodopa using floatable spray-coated microcapsules for the management of Parkinson’s disease

• Main Authors: Baek, Jong-Suep, Tee, Jie Kai, Pang, Yi Yun, Tan, Ern Yu, Lim, Kah Leong, Ho, Han Kiat, Loo, Joachim Say Chye
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: Controlled Release; DRNTU::Engineering::Materials; Levodopa-induced Dyskinesia
• Online Access: https://hdl.handle.net/10356/92269; http://hdl.handle.net/10220/49468
• Institution: Nanyang Technological University

Oral administration of levodopa (LD) is the gold standard in managing Parkinson’s disease (PD). Although LD is the most effective drug in treating PD, chronic administration of LD induces levodopa-induced dyskinesia. A continuous and sustained provision of LD to the brain could, therefore, reduce pe...