Computer modelling of connectivity change suggests epileptogenesis mechanisms in idiopathic generalised epilepsy

• Main Authors: Sinha, Nishant, Wang, Yujiang, Dauwels, Justin, Kaiser, Marcus, Thesen, Thomas, Forsyth, Rob, Taylor, Peter Neal
• Other Authors: School of Electrical and Electronic Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: Computational Model; DRNTU::Engineering::Electrical and electronic engineering; Diagnosis
• Online Access: https://hdl.handle.net/10356/93145; http://hdl.handle.net/10220/48525
• Institution: Nanyang Technological University

Patients with idiopathic generalised epilepsy (IGE) typically have normal conventional magnetic resonance imaging (MRI), hence diagnosis based on MRI is challenging. Anatomical abnormalities underlying brain dysfunctions in IGE are unclear and their relation to the pathomechanisms of epileptogenesis...