Tetratricopeptide repeat domain 9A negatively regulates estrogen receptor alpha activity

• Main Authors: Shrestha, Smeeta, Sun, Yang, Lufkin, Thomas, Kraus, Petra, Or, Yuzuan, Garcia, Yenni A., Guy, Naihsuan, Ramos, Paola, Cox, Marc B., Tay, Fiona, Lin, Valerie Chun Ling
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/93737; http://hdl.handle.net/10220/38344
• Institution: Nanyang Technological University

Tetratricopeptide repeat domain 9A (TTC9A) is a target gene of estrogen and progesterone. It is over-expressed in breast cancer. However, little is known about the physiological function of TTC9A. The objectives of this study were to establish a Ttc9a knockout mouse model and to study the consequenc...