Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves

Mesoporous silica nanoparticles (MSNP) have proven to be an extremely effective solid support for controlled drug delivery on account of the fact that their surfaces can be...

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Main Authors: Nel, Andre E., Zink, Jeffrey I., Meng, Huan, Xue, Min, Xia, Tian, Zhao, Yanli, Tamanoi, Fuyuhiko, Stoddart, J. Fraser
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2011
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Online Access:https://hdl.handle.net/10356/93792
http://hdl.handle.net/10220/7048
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-937922022-02-16T16:30:22Z Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves Nel, Andre E. Zink, Jeffrey I. Meng, Huan Xue, Min Xia, Tian Zhao, Yanli Tamanoi, Fuyuhiko Stoddart, J. Fraser School of Physical and Mathematical Sciences DRNTU::Science::Biological sciences::Biochemistry Mesoporous silica nanoparticles (MSNP) have proven to be an extremely effective solid support for controlled drug delivery on account of the fact that their surfaces can be easily functionalized in order to control the nanopore openings. We have described recently a series of mechanized silica nanoparticles, which, under abiotic conditions, are capable of delivering cargo molecules employing a series of nanovalves. The key question for these systems has now become whether they can be adapted for biological use through controlled nanovalve opening in cells. Herein, we report a novel MSNP delivery system capable of drug delivery based on the function of -cyclodextrin ( -CD) nanovalves that are responsive to the endosomal acidification conditions in human differentiated myeloid (THP-1) and squamous carcinoma (KB- 31) cell lines. Furthermore, we demonstrate how to optimize the surface functionalization of the MSNP so as to provide a platform for the effective and rapid doxorubicin release to the nuclei of KB-31 cells. 2011-09-14T07:17:04Z 2019-12-06T18:45:40Z 2011-09-14T07:17:04Z 2019-12-06T18:45:40Z 2010 2010 Journal Article Meng, H., Xue, M., Xia, T., Zhao, Y. L., Tamanoi, F., Stoddart, J. F., & et al. (2010). Autonomous in Vitro Anticancer Drug Release from Mesoporous Silica Nanoparticles by pH-Sensitive Nanovalves. Journal of the American Chemical Society, 132(36), 12690-12697. 0002-7863 https://hdl.handle.net/10356/93792 http://hdl.handle.net/10220/7048 10.1021/ja104501a 20718462 159765 en Journal of the American chemical society © 2010 American Chemical Society 8 p.
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Biological sciences::Biochemistry
spellingShingle DRNTU::Science::Biological sciences::Biochemistry
Nel, Andre E.
Zink, Jeffrey I.
Meng, Huan
Xue, Min
Xia, Tian
Zhao, Yanli
Tamanoi, Fuyuhiko
Stoddart, J. Fraser
Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves
description Mesoporous silica nanoparticles (MSNP) have proven to be an extremely effective solid support for controlled drug delivery on account of the fact that their surfaces can be easily functionalized in order to control the nanopore openings. We have described recently a series of mechanized silica nanoparticles, which, under abiotic conditions, are capable of delivering cargo molecules employing a series of nanovalves. The key question for these systems has now become whether they can be adapted for biological use through controlled nanovalve opening in cells. Herein, we report a novel MSNP delivery system capable of drug delivery based on the function of -cyclodextrin ( -CD) nanovalves that are responsive to the endosomal acidification conditions in human differentiated myeloid (THP-1) and squamous carcinoma (KB- 31) cell lines. Furthermore, we demonstrate how to optimize the surface functionalization of the MSNP so as to provide a platform for the effective and rapid doxorubicin release to the nuclei of KB-31 cells.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Nel, Andre E.
Zink, Jeffrey I.
Meng, Huan
Xue, Min
Xia, Tian
Zhao, Yanli
Tamanoi, Fuyuhiko
Stoddart, J. Fraser
format Article
author Nel, Andre E.
Zink, Jeffrey I.
Meng, Huan
Xue, Min
Xia, Tian
Zhao, Yanli
Tamanoi, Fuyuhiko
Stoddart, J. Fraser
author_sort Nel, Andre E.
title Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves
title_short Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves
title_full Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves
title_fullStr Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves
title_full_unstemmed Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves
title_sort autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by ph-sensitive nanovalves
publishDate 2011
url https://hdl.handle.net/10356/93792
http://hdl.handle.net/10220/7048
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