Optimization of isocratic supercritical fluid chromatography for enantiomer separation

• Main Authors: Chen, Wenda, Reza Haghpanah, Arvind Rajendran, Mohammad Amanullah
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Organic chromatography
• Online Access: https://hdl.handle.net/10356/93930; http://hdl.handle.net/10220/7187
• Institution: Nanyang Technological University

This paper presents multi-objective optimization analysis and experimental implementation of a single column isocratic supercritical fluid chromatography process for the enantioseparation of flurbiprofen. The single column process is simulated using a detailed model with equilibrium description by a...