Discovery and characterization of novel cyclotides originated from chimeric precursors consisting of Albumin-1 chain a and cyclotide domains in the Fabaceae family

• Main Authors: Nguyen, Giang Kien Truc, Zhang, Sen, Nguyen, Ngan Thi Kim, Nguyen, Phuong Quoc Thuc, Chiu, Ming Sheau, Hardjojo, Antony, Tam, James P.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Biological sciences::Botany
• Online Access: https://hdl.handle.net/10356/93943; http://hdl.handle.net/10220/7205
• Institution: Nanyang Technological University

The tropical plant Clitoria ternatea is a member of the Fabaceae family well known for its medicinal values. Heat extraction of C. ternatea revealed that the bioactive fractions contained heat-stable cysteine-rich peptides (CRPs). The CRP family of A1b (Albumin-1 chain b/leginsulins), which is a lin...