Structural characterization of the interaction between a Pleckstrin homology domain and phosphatidylinositol 4,5-bisphosphate

• Main Authors: Harlan, John E., Hajduk, Philip J., Fesik, Stephen W., Yoon, Ho Sup
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2012
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: https://hdl.handle.net/10356/94072; http://hdl.handle.net/10220/7467
• Institution: Nanyang Technological University

The pleckstrin homology (PH) domain is a protein module of approximately 100 amino acids that is found in several proteins involved in signal transduction [for a recent review, see Gibson et al. (1994) Trends Biochem. Sci. 19,349-3531. Although the specific function of the PH domain has not ye...