Self-assembly behavior of inclusion complex formed by β-cyclodextrin with α-aminopyridine
An inclusion complex (1) has been prepared by β-cyclodextrin with α-aminopyridine The result of X-ray crystallographic analyses showed that the α-aminopyridine molecules in...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/94264 http://hdl.handle.net/10220/6973 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | An inclusion complex (1) has been prepared by β-cyclodextrin with α-aminopyridine
The result of X-ray crystallographic analyses showed that the α-aminopyridine molecules in the
β-cyclodextrin cavities possess two opposite orientations, i.e. the amine group of α-aminopyridine
pointing to the primary side (1a, occupancy: 41.2%) or the secondary side (1b, occupancy:
58.8%) of β-cyclodextrin, forming two scalelike supramolecular aggregations. The studies of 2D
NMR and circular dichroism spectra indicated that the α-aminopyridine molecule is deeply embedded
in the β-cyclodextrin cavity to form host-guest inclusion complex, showing a circular dichroism
spectrum induced by the chiral cavity of cyclodextrin. The results obtained are helpful for
understanding the molecular recognition and aggregation mechanism between the host and
guest. |
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