Sugar-based synthesis of Tamiflu and its inhibitory effects on cell secretion

• Main Authors: Ma, Jimei, Zhao, Yanying, Ng, Simon, Zeng, Jing, Than, Aung, Chen, Peng, Liu, Xue-Wei, Zhang, Jing
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2012
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: https://hdl.handle.net/10356/94305; http://hdl.handle.net/10220/7486
• Institution: Nanyang Technological University

Tamiflu is currently the most effective drug for the treatment of influenza, but the insufficient supply and side-effects of this drug demand urgent solutions. We present a practical synthesis of Tamiflu by using novel synthetic routes, cheap reagents, and the abundantly available starting material...