Sugar-based synthesis of Tamiflu and its inhibitory effects on cell secretion

• Main Authors: Ma, Jimei, Zhao, Yanying, Ng, Simon, Zeng, Jing, Than, Aung, Chen, Peng, Liu, Xue-Wei, Zhang, Jing
• 其他作者: School of Physical and Mathematical Sciences
• 格式: Article
• 語言: English
• 出版: 2012
• 主題: DRNTU::Science::Biological sciences::Biochemistry
• 在線閱讀: https://hdl.handle.net/10356/94305; http://hdl.handle.net/10220/7486
• 機構: Nanyang Technological University

Tamiflu is currently the most effective drug for the treatment of influenza, but the insufficient supply and side-effects of this drug demand urgent solutions. We present a practical synthesis of Tamiflu by using novel synthetic routes, cheap reagents, and the abundantly available starting material...