Sugar-based synthesis of Tamiflu and its inhibitory effects on cell secretion

• المؤلفون الرئيسيون: Ma, Jimei, Zhao, Yanying, Ng, Simon, Zeng, Jing, Than, Aung, Chen, Peng, Liu, Xue-Wei, Zhang, Jing
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2012
• الموضوعات: DRNTU::Science::Biological sciences::Biochemistry
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/94305; http://hdl.handle.net/10220/7486
• المؤسسة: Nanyang Technological University

Tamiflu is currently the most effective drug for the treatment of influenza, but the insufficient supply and side-effects of this drug demand urgent solutions. We present a practical synthesis of Tamiflu by using novel synthetic routes, cheap reagents, and the abundantly available starting material...