Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

• Main Authors: Harlan, John E., Hajduk, Philip J., Fesik, Stephen W., Yoon, Ho Sup
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2012
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: https://hdl.handle.net/10356/94313; http://hdl.handle.net/10220/7633
• Institution: Nanyang Technological University

THE pleckstrin homology (PH) domain is a new protein module of around 100 amino acids found in several proteins involved in signal transduction1–5. Although its specific function has yet to be elucidated, the carboxy-terminal regions of many βγ domains bind to the py subunits of G proteins6,7. On th...