Nanoelectronic biosensing of dynamic cellular activities based on nanostructured materials
Detecting subtle cellular activities that occur dynamically as regulated temporally and spatially by molecular machinery is of obvious importance in fundamental biology as well as in drug discovery. Additionally, it demands fast and sensitive detection modality. The emerging nanoelectronic...
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| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/94393 http://hdl.handle.net/10220/7496 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Detecting subtle cellular activities that occur dynamically as regulated temporally
and spatially by molecular machinery is of obvious importance in fundamental
biology as well as in drug discovery. Additionally, it demands fast and
sensitive detection modality. The emerging nanoelectronic biosensors based
on nanostructured materials have shown promising potential to resolve
the dynamic biological processes of living cells with high sensitivity and high
temporal and spatial resolution. Here, the recent advances in the nanoelectronic
biosensing of regulated secretion of biomolecules and bioelectrical
activities of ion channels using carbon nanotubes and silicon nanowires are
briefl y reviewed. The perspectives and key issues of future development are
also discussed. |
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