An efficient microfluidic sorter : implementation of double meandering micro striplines for magnetic particles switching
The ability to trap, manipulate, and separate magnetic beads has become one of the key requirements in realizing an integrated magnetic lab-on-chip biosensing system. In this article, we present the design and fabrication of an integrated magneto-fluidic device for sorting magnetic particles with a...
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sg-ntu-dr.10356-945412023-03-04T17:18:40Z An efficient microfluidic sorter : implementation of double meandering micro striplines for magnetic particles switching Kong, Tian Fook E, Huan Shin Sugiarto, Hendrik Santoso Liew, Hwi Fen Wang, Xinghua Lew, Wen Siang Nguyen, Nam-Trung Chen, Yong School of Mechanical and Aerospace Engineering DRNTU::Engineering::Mechanical engineering The ability to trap, manipulate, and separate magnetic beads has become one of the key requirements in realizing an integrated magnetic lab-on-chip biosensing system. In this article, we present the design and fabrication of an integrated magneto-fluidic device for sorting magnetic particles with a sorting efficiency of up to 95%. The actuation and manipulation of magnetic beads are realized using microfabricated square meandering current-carrying micro striplines. The current is alternated between two neighboring micro striplines to switch the magnetic beads to either one of the two outlets. We performed a series of parametric study to investigate the effect of applied current, flow rate, and switching frequency on the sorting efficiency. Experimental results reveal that the sorting efficiency is proportional to the square of current applied to the stripline, and decreases with increasing buffer flow rate and switching frequency. Such phenomena agree well with our theoretical analysis and simulation result. The fastest switching rate, which is limited by the microchannel geometry and bead velocity, is 2 Hz. 2012-04-11T08:42:13Z 2019-12-06T18:57:42Z 2012-04-11T08:42:13Z 2019-12-06T18:57:42Z 2010 2010 Journal Article Kong, T. F., E, H. S., Sugiarto, H. S., Liew, H. F., Wang, X., Lew, W. S., et al. (2011). An efficient microfluidic sorter: implementation of double meandering micro striplines for magnetic particles switching. Microfluidics and Nanofluidics, 10(5), 1069-1078. https://hdl.handle.net/10356/94541 http://hdl.handle.net/10220/7731 10.1007/s10404-010-0735-8 159431 en Microfluidics and nanofluidics © 2010 Springer-Verlag. This is the author created version of a work that has been peer reviewed and accepted for publication by Microfluidics and nanofluidics, Springer-Verlag. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at:[DOI: http://dx.doi.org/10.1007/s10404-010-0735-8] 17 p. application/pdf |
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DRNTU::Engineering::Mechanical engineering Kong, Tian Fook E, Huan Shin Sugiarto, Hendrik Santoso Liew, Hwi Fen Wang, Xinghua Lew, Wen Siang Nguyen, Nam-Trung Chen, Yong An efficient microfluidic sorter : implementation of double meandering micro striplines for magnetic particles switching |
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The ability to trap, manipulate, and separate magnetic beads has become one of the key requirements in realizing an integrated magnetic lab-on-chip biosensing system. In this article, we present the design and fabrication of an integrated magneto-fluidic device for sorting magnetic particles with a sorting efficiency of up to 95%. The actuation and manipulation of magnetic beads are realized using microfabricated square meandering current-carrying micro striplines. The current is alternated between two neighboring micro striplines to switch the magnetic beads to either one of the two outlets. We performed a series of parametric study to investigate the effect of applied current, flow rate, and switching frequency on the sorting efficiency. Experimental results reveal that the sorting efficiency is proportional to the square of current applied to the stripline, and decreases with increasing buffer flow rate and switching frequency. Such phenomena agree well with our theoretical analysis and simulation result. The fastest switching rate, which is limited by the microchannel geometry and bead velocity, is 2 Hz. |
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School of Mechanical and Aerospace Engineering |
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School of Mechanical and Aerospace Engineering Kong, Tian Fook E, Huan Shin Sugiarto, Hendrik Santoso Liew, Hwi Fen Wang, Xinghua Lew, Wen Siang Nguyen, Nam-Trung Chen, Yong |
format |
Article |
author |
Kong, Tian Fook E, Huan Shin Sugiarto, Hendrik Santoso Liew, Hwi Fen Wang, Xinghua Lew, Wen Siang Nguyen, Nam-Trung Chen, Yong |
author_sort |
Kong, Tian Fook |
title |
An efficient microfluidic sorter : implementation of double meandering micro striplines for magnetic particles switching |
title_short |
An efficient microfluidic sorter : implementation of double meandering micro striplines for magnetic particles switching |
title_full |
An efficient microfluidic sorter : implementation of double meandering micro striplines for magnetic particles switching |
title_fullStr |
An efficient microfluidic sorter : implementation of double meandering micro striplines for magnetic particles switching |
title_full_unstemmed |
An efficient microfluidic sorter : implementation of double meandering micro striplines for magnetic particles switching |
title_sort |
efficient microfluidic sorter : implementation of double meandering micro striplines for magnetic particles switching |
publishDate |
2012 |
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https://hdl.handle.net/10356/94541 http://hdl.handle.net/10220/7731 |
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1759855194380697600 |