Identification of functional motifs in HBX genotype D and their roles in cellular processes

• Main Author: Lee, Kar Kei
• Other Authors: William Chen Wei Ning
• Format: Student Research Poster
• Language: English
• Published: 2013
• Subjects: HBX genotype D; SH3 binding domain
• Online Access: https://hdl.handle.net/10356/94561; http://hdl.handle.net/10220/9061
• Institution: Nanyang Technological University

“ Hepatitis B virus infection…2 billion people infected world wide and 350 million suffering from chronic HBV. It is the 10th leading cause of death. “(World Health Organization) The viral regulatory protein HBX genotype B has been found to trigger apoptosis in HBV-infected cells.[1] Other studies has also shown that HBX genotype B protein was able to activate Rac1 signaling pathway and induce membrane ruffling of cells.[2] However, HBX genotype D has slightly different protein sequence compared to other genotypes. This research will focus on investigating the functional motifs or conserved domains present in HBX genotype D and the roles that these motifs play in HBV replication induced cell expressions. [2nd Award]