Towards sustainable preparation of oral solid dosage form of drug nanoparticles
Advanced drug discovery techniques have led to identifications of complex chemical compounds with excellent therapeutic potentials. However, many of these compounds exhibit poor aqueous solubility1 and lead to incomplete, erratic and slow systemic absorption. To enhance drug solubility as well as bi...
Saved in:
Main Author: | |
---|---|
Other Authors: | |
Format: | Student Research Poster |
Language: | English |
Published: |
2013
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/95079 http://hdl.handle.net/10220/8980 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Nanyang Technological University |
Language: | English |
id |
sg-ntu-dr.10356-95079 |
---|---|
record_format |
dspace |
spelling |
sg-ntu-dr.10356-950792020-09-27T20:27:39Z Towards sustainable preparation of oral solid dosage form of drug nanoparticles Jia, Tong Kunn Hadinoto School of Chemical and Biomedical Engineering Ionic cross-linking Nanoparticle Advanced drug discovery techniques have led to identifications of complex chemical compounds with excellent therapeutic potentials. However, many of these compounds exhibit poor aqueous solubility1 and lead to incomplete, erratic and slow systemic absorption. To enhance drug solubility as well as bioavailability, formulating the active pharmaceutical ingredients (API) into nano-particles (NPs) has been proven to be simple and effective2. To improve flow properties and compaction characteristics within further tablets and capsules manufacturing process (Figure 1), nano-API are adsorbed onto the agglomeration templates to produce hierarchically-ordered micro-granules of the NPs. Many of current nano-API production and micro-granulation techniques, however, possess low energy and mass efficiency due to the harsh operating conditions3. A more sustainable manufacturing process of nano-API and micro-granules operated at ambient temperature, pressure, neutral pH, and absent of organic solvent, is studied in this project. [1st Award] 2013-01-31T02:08:06Z 2019-12-06T19:07:47Z 2013-01-31T02:08:06Z 2019-12-06T19:07:47Z 2012 2012 Student Research Poster Jia, T. (2012, March). Towards sustainable preparation of oral solid dosage form of drug nanoparticles. Presented at Discover URECA @ NTU poster exhibition and competition, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/95079 http://hdl.handle.net/10220/8980 en © 2012 The Author(s). application/pdf |
institution |
Nanyang Technological University |
building |
NTU Library |
country |
Singapore |
collection |
DR-NTU |
language |
English |
topic |
Ionic cross-linking Nanoparticle |
spellingShingle |
Ionic cross-linking Nanoparticle Jia, Tong Towards sustainable preparation of oral solid dosage form of drug nanoparticles |
description |
Advanced drug discovery techniques have led to identifications of complex chemical compounds with excellent therapeutic potentials. However, many of these compounds exhibit poor aqueous solubility1 and lead to incomplete, erratic and slow systemic absorption. To enhance drug solubility as well as bioavailability, formulating the active pharmaceutical ingredients (API) into nano-particles (NPs) has been proven to be simple and effective2. To improve flow properties and compaction characteristics within further tablets and capsules manufacturing process (Figure 1), nano-API are adsorbed onto the agglomeration templates to produce hierarchically-ordered micro-granules of the NPs. Many of current nano-API production and micro-granulation techniques, however, possess low energy and mass efficiency due to the harsh operating conditions3. A more sustainable manufacturing process of nano-API and micro-granules operated at ambient temperature, pressure, neutral pH, and absent of organic solvent, is studied in this project. [1st Award] |
author2 |
Kunn Hadinoto |
author_facet |
Kunn Hadinoto Jia, Tong |
format |
Student Research Poster |
author |
Jia, Tong |
author_sort |
Jia, Tong |
title |
Towards sustainable preparation of oral solid dosage form of drug nanoparticles |
title_short |
Towards sustainable preparation of oral solid dosage form of drug nanoparticles |
title_full |
Towards sustainable preparation of oral solid dosage form of drug nanoparticles |
title_fullStr |
Towards sustainable preparation of oral solid dosage form of drug nanoparticles |
title_full_unstemmed |
Towards sustainable preparation of oral solid dosage form of drug nanoparticles |
title_sort |
towards sustainable preparation of oral solid dosage form of drug nanoparticles |
publishDate |
2013 |
url |
https://hdl.handle.net/10356/95079 http://hdl.handle.net/10220/8980 |
_version_ |
1681056430245806080 |