Towards sustainable preparation of oral solid dosage form of drug nanoparticles

Advanced drug discovery techniques have led to identifications of complex chemical compounds with excellent therapeutic potentials. However, many of these compounds exhibit poor aqueous solubility1 and lead to incomplete, erratic and slow systemic absorption. To enhance drug solubility as well as bi...

Full description

Saved in:
Bibliographic Details
Main Author: Jia, Tong
Other Authors: Kunn Hadinoto
Format: Student Research Poster
Language:English
Published: 2013
Subjects:
Online Access:https://hdl.handle.net/10356/95079
http://hdl.handle.net/10220/8980
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-95079
record_format dspace
spelling sg-ntu-dr.10356-950792020-09-27T20:27:39Z Towards sustainable preparation of oral solid dosage form of drug nanoparticles Jia, Tong Kunn Hadinoto School of Chemical and Biomedical Engineering Ionic cross-linking Nanoparticle Advanced drug discovery techniques have led to identifications of complex chemical compounds with excellent therapeutic potentials. However, many of these compounds exhibit poor aqueous solubility1 and lead to incomplete, erratic and slow systemic absorption. To enhance drug solubility as well as bioavailability, formulating the active pharmaceutical ingredients (API) into nano-particles (NPs) has been proven to be simple and effective2. To improve flow properties and compaction characteristics within further tablets and capsules manufacturing process (Figure 1), nano-API are adsorbed onto the agglomeration templates to produce hierarchically-ordered micro-granules of the NPs. Many of current nano-API production and micro-granulation techniques, however, possess low energy and mass efficiency due to the harsh operating conditions3. A more sustainable manufacturing process of nano-API and micro-granules operated at ambient temperature, pressure, neutral pH, and absent of organic solvent, is studied in this project. [1st Award] 2013-01-31T02:08:06Z 2019-12-06T19:07:47Z 2013-01-31T02:08:06Z 2019-12-06T19:07:47Z 2012 2012 Student Research Poster Jia, T. (2012, March). Towards sustainable preparation of oral solid dosage form of drug nanoparticles. Presented at Discover URECA @ NTU poster exhibition and competition, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/95079 http://hdl.handle.net/10220/8980 en © 2012 The Author(s). application/pdf
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Ionic cross-linking
Nanoparticle
spellingShingle Ionic cross-linking
Nanoparticle
Jia, Tong
Towards sustainable preparation of oral solid dosage form of drug nanoparticles
description Advanced drug discovery techniques have led to identifications of complex chemical compounds with excellent therapeutic potentials. However, many of these compounds exhibit poor aqueous solubility1 and lead to incomplete, erratic and slow systemic absorption. To enhance drug solubility as well as bioavailability, formulating the active pharmaceutical ingredients (API) into nano-particles (NPs) has been proven to be simple and effective2. To improve flow properties and compaction characteristics within further tablets and capsules manufacturing process (Figure 1), nano-API are adsorbed onto the agglomeration templates to produce hierarchically-ordered micro-granules of the NPs. Many of current nano-API production and micro-granulation techniques, however, possess low energy and mass efficiency due to the harsh operating conditions3. A more sustainable manufacturing process of nano-API and micro-granules operated at ambient temperature, pressure, neutral pH, and absent of organic solvent, is studied in this project. [1st Award]
author2 Kunn Hadinoto
author_facet Kunn Hadinoto
Jia, Tong
format Student Research Poster
author Jia, Tong
author_sort Jia, Tong
title Towards sustainable preparation of oral solid dosage form of drug nanoparticles
title_short Towards sustainable preparation of oral solid dosage form of drug nanoparticles
title_full Towards sustainable preparation of oral solid dosage form of drug nanoparticles
title_fullStr Towards sustainable preparation of oral solid dosage form of drug nanoparticles
title_full_unstemmed Towards sustainable preparation of oral solid dosage form of drug nanoparticles
title_sort towards sustainable preparation of oral solid dosage form of drug nanoparticles
publishDate 2013
url https://hdl.handle.net/10356/95079
http://hdl.handle.net/10220/8980
_version_ 1681056430245806080