Modify the "vault" for a better drug delivery capsule
The vault is a protein naturally occurring in most eukaryotic-cell organisms, except for fruit fly, a type of worm and yeast. It is most frequently suggested with some transportation function within the cell. The key components in the vault we are manipulating are the major vault proteins (MVPs) (...
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sg-ntu-dr.10356-951012020-09-27T20:29:14Z Modify the "vault" for a better drug delivery capsule Mao, Ning Lim Sierin School of Chemical and Biomedical Engineering The vault is a protein naturally occurring in most eukaryotic-cell organisms, except for fruit fly, a type of worm and yeast. It is most frequently suggested with some transportation function within the cell. The key components in the vault we are manipulating are the major vault proteins (MVPs) (green) and the minimal interacting domain (mINT) (red). Naturally the vault can disassemble under a pH lower than 4. The vault can be a good drug delivery capsule, due to its large capacity and bio-compatibility. Therapeutic molecules can be fused to mINT and easily enclosed into the vault shell. [Peer Assessment Review] 2013-01-31T02:27:28Z 2019-12-06T19:08:14Z 2013-01-31T02:27:28Z 2019-12-06T19:08:14Z 2012 2012 Student Research Poster Mao, N. (2012, March). Modify the "vault" for a better drug delivery capsule. Presented at Discover URECA @ NTU poster exhibition and competition, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/95101 http://hdl.handle.net/10220/8985 en © 2012 The Author(s). application/pdf |
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English |
| description |
The vault is a protein naturally occurring in most eukaryotic-cell organisms, except for fruit fly, a type of worm and yeast.
It is most frequently suggested with some transportation function within the cell.
The key components in the vault we are manipulating are the major vault proteins (MVPs) (green) and the minimal
interacting domain (mINT) (red). Naturally the vault can disassemble under a pH lower than 4.
The vault can be a good drug delivery capsule, due to its large capacity and bio-compatibility.
Therapeutic molecules can be fused to mINT and easily enclosed into the vault shell. [Peer Assessment Review] |
| author2 |
Lim Sierin |
| author_facet |
Lim Sierin Mao, Ning |
| format |
Student Research Poster |
| author |
Mao, Ning |
| spellingShingle |
Mao, Ning Modify the "vault" for a better drug delivery capsule |
| author_sort |
Mao, Ning |
| title |
Modify the "vault" for a better drug delivery capsule |
| title_short |
Modify the "vault" for a better drug delivery capsule |
| title_full |
Modify the "vault" for a better drug delivery capsule |
| title_fullStr |
Modify the "vault" for a better drug delivery capsule |
| title_full_unstemmed |
Modify the "vault" for a better drug delivery capsule |
| title_sort |
modify the "vault" for a better drug delivery capsule |
| publishDate |
2013 |
| url |
https://hdl.handle.net/10356/95101 http://hdl.handle.net/10220/8985 |
| _version_ |
1681058045139877888 |