Phenotype of human epidermis with sIL-1ra deficiency
Skin is the largest organ in the body and it serves as a protective barrier. It is made up of an outermost epidermal layer and an underlying dermal layer (Fig 1). The formation and maintenance of the epidermis depend on the precise regulation of keratinocyte proliferation, differentiation and...
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| Main Author: | |
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| Other Authors: | |
| Format: | Student Research Poster |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/95257 http://hdl.handle.net/10220/8989 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Skin is the largest organ in the body and it serves as a protective barrier. It is made up of an outermost
epidermal layer and an underlying dermal layer (Fig 1). The formation and maintenance of the epidermis depend
on the precise regulation of keratinocyte proliferation, differentiation and apoptosis. This homeostasis relies on
the network of cytokines and growth factors. Perturbation of this homeostasis leads to inflammatory skin
diseases and cancer development. Interleukin-1 (IL-1) is a pro-inflammatory cytokine that is constitutively
produced by keratinocytes. It is also involved in the proliferation and
differentiation of keratinocytes. IL-1 binds to its cognate receptor and
can trigger downstream pathways with different outcomes. sIL-1ra
binds to IL-1 receptor and prevents the transmission of intracellular
response. However, the phenotype of human epidermis when the
underlying fibroblast cells is deficient of sIL-1ra remains unclear. [3rd Award] |
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