Nanostructural characteristics, mechanical properties, and osteoblast response of spark plasma sintered hydroxyapatite

This study aimed to fabricate bulk nanostructured hydroxyapatite (HA) pellets with improved properties using spark plasma sintering (SPS) for orthopedic applications. Spray-dried nanostructured HA (nSD-HA) powders were consolidated using the rapid SPS processing. The SPS processed nSD-HA was charact...

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Main Authors: Li, H., Chow, V., Cheang, P., Khor, Khiam Aik
Other Authors: School of Mechanical and Aerospace Engineering
Format: Article
Language:English
Published: 2012
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Online Access:https://hdl.handle.net/10356/95264
http://hdl.handle.net/10220/8422
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-952642020-03-07T11:35:24Z Nanostructural characteristics, mechanical properties, and osteoblast response of spark plasma sintered hydroxyapatite Li, H. Chow, V. Cheang, P. Khor, Khiam Aik School of Mechanical and Aerospace Engineering DRNTU::Engineering::Mechanical engineering This study aimed to fabricate bulk nanostructured hydroxyapatite (HA) pellets with improved properties using spark plasma sintering (SPS) for orthopedic applications. Spray-dried nanostructured HA (nSD-HA) powders were consolidated using the rapid SPS processing. The SPS processed nSD-HA was characterized using Raman spectroscopy and field emission scanning electron microscopy (FESEM). Mechanical properties of the consolidates were also evaluated through indentation approach. The nanostructures (∼80 nm in grain size) of the starting powders were successfully retained after the SPS processing operated at 950°C with <15 min holding time. The SPS consolidated nSD-HA showed promising mechanical properties, ∼118 GPa for Young's modulus, and up to 2.22 MPa m0.5 for fracture toughness. SPS holding time showed minor influence on the phases of the pellets. Furthermore, the spheroidized nanostructured HA retained the HA structure after the SPS consolidation. Preliminary cytotoxicity and cell attachment studies were also carried out using a human osteoblast cell line hFOB 1.19. Enhanced cell attachment and proliferation on the nanostructured pellets were revealed. The presence of the nanostructures accounts mainly for the enhanced mechanical properties and promoted proliferation of the osteoblast cells. This study suggests that the SPS technique is an appropriate process for fabrication of bulk nSD-HA from nanostructured powder. 2012-08-24T03:44:33Z 2019-12-06T19:11:32Z 2012-08-24T03:44:33Z 2019-12-06T19:11:32Z 2007 2007 Journal Article Li, H., Khor, K. A., Chow, V., & Cheang, P. (2007). Nanostructural characteristics, mechanical properties, and osteoblast response of spark plasma sintered hydroxyapatite. Journal of Biomedical Materials Research Part A, 82A(2), 296-303. 1552-4965 https://hdl.handle.net/10356/95264 http://hdl.handle.net/10220/8422 10.1002/jbm.a.31143 en Journal of biomedical materials research Part A © 2007 Wiley Periodicals, Inc.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic DRNTU::Engineering::Mechanical engineering
spellingShingle DRNTU::Engineering::Mechanical engineering
Li, H.
Chow, V.
Cheang, P.
Khor, Khiam Aik
Nanostructural characteristics, mechanical properties, and osteoblast response of spark plasma sintered hydroxyapatite
description This study aimed to fabricate bulk nanostructured hydroxyapatite (HA) pellets with improved properties using spark plasma sintering (SPS) for orthopedic applications. Spray-dried nanostructured HA (nSD-HA) powders were consolidated using the rapid SPS processing. The SPS processed nSD-HA was characterized using Raman spectroscopy and field emission scanning electron microscopy (FESEM). Mechanical properties of the consolidates were also evaluated through indentation approach. The nanostructures (∼80 nm in grain size) of the starting powders were successfully retained after the SPS processing operated at 950°C with <15 min holding time. The SPS consolidated nSD-HA showed promising mechanical properties, ∼118 GPa for Young's modulus, and up to 2.22 MPa m0.5 for fracture toughness. SPS holding time showed minor influence on the phases of the pellets. Furthermore, the spheroidized nanostructured HA retained the HA structure after the SPS consolidation. Preliminary cytotoxicity and cell attachment studies were also carried out using a human osteoblast cell line hFOB 1.19. Enhanced cell attachment and proliferation on the nanostructured pellets were revealed. The presence of the nanostructures accounts mainly for the enhanced mechanical properties and promoted proliferation of the osteoblast cells. This study suggests that the SPS technique is an appropriate process for fabrication of bulk nSD-HA from nanostructured powder.
author2 School of Mechanical and Aerospace Engineering
author_facet School of Mechanical and Aerospace Engineering
Li, H.
Chow, V.
Cheang, P.
Khor, Khiam Aik
format Article
author Li, H.
Chow, V.
Cheang, P.
Khor, Khiam Aik
author_sort Li, H.
title Nanostructural characteristics, mechanical properties, and osteoblast response of spark plasma sintered hydroxyapatite
title_short Nanostructural characteristics, mechanical properties, and osteoblast response of spark plasma sintered hydroxyapatite
title_full Nanostructural characteristics, mechanical properties, and osteoblast response of spark plasma sintered hydroxyapatite
title_fullStr Nanostructural characteristics, mechanical properties, and osteoblast response of spark plasma sintered hydroxyapatite
title_full_unstemmed Nanostructural characteristics, mechanical properties, and osteoblast response of spark plasma sintered hydroxyapatite
title_sort nanostructural characteristics, mechanical properties, and osteoblast response of spark plasma sintered hydroxyapatite
publishDate 2012
url https://hdl.handle.net/10356/95264
http://hdl.handle.net/10220/8422
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