Ribosome engineering to promote new crystal forms

• Main Authors: Ramakrishnan, V., Selmer, Maria, Gao, Yong-Gui, Weixlbaumer, Albert
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Chemistry::Biochemistry; DRNTU::Science::Chemistry::Crystallography
• Online Access: https://hdl.handle.net/10356/95314; http://hdl.handle.net/10220/9266
• Institution: Nanyang Technological University

Crystallographic studies of the ribosome have provided molecular details of protein synthesis. However, the crystallization of functional complexes of ribosomes with GTPase translation factors proved to be elusive for a decade after the first ribosome structures were determined. Analysis of the pack...