Dachshund depletion disrupts mammary gland development and diverts the composition of the mammary gland progenitor pool

• Main Authors: Jiao, Xuanmao, Li, Zhiping, Wang, Min, Katiyar, Sanjay, Di Sante, Gabriele, Farshchian, Mehdi, Wu, Kongming, Tabas, Ira, Spike, Benjamin T., South, Andrew P., Cocola, Cinzia, Colombo, Daniele, Reinbold, Rolland, Zucchi, Ileana, Pestell, Richard George
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Medicine; DACH; Mammary Gland
• Online Access: https://hdl.handle.net/10356/95390; http://hdl.handle.net/10220/48526
• Institution: Nanyang Technological University

DACH1 abundance is reduced in human malignancies, including breast cancer. Herein DACH1 was detected among multipotent fetal mammary stem cells in the embryo, among mixed lineage precursors, and in adult basal cells and (ERα+) luminal progenitors. Dach1 gene deletion at 6 weeks in transgenic mice re...