Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility

• Main Authors: Kurochkin, Igor V., Alkuraya, Fowzan S., Iwasa, Hiroyasu, Akita, Masumi, Tsukui, Tohru, Ito, Chizuru, Shimozawa, Nobuyuki, Iseki, Mioko, Mizuno, Yumi, Ninomiya, Yuichi, Nakachi, Yutaka, Toshimori, Kiyotaka, Nishimukai, Megumi, Hara, Hiroshi, Maeba, Ryouta, Okazaki, Tomoki, Alodaib, Ali Nasser Ali, Amoudi, Mohammed Al, Jacob, Minnie, Horai, Yasushi, Watanabe, Mitsuhiro, Motegi, Hiromi, Wakana, Shigeharu, Noda, Tetsuo, Mizuno, Yosuke, Schönbach, Christian, Okazaki, Yasushi
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/95877; http://hdl.handle.net/10220/11902
• Institution: Nanyang Technological University

Peroxisomes are subcellular organelles involved in lipid metabolic processes, including those of very-long-chain fatty acids and branched-chain fatty acids, among others. Peroxisome matrix proteins are synthesized in the cytoplasm. Targeting signals (PTS or peroxisomal targeting signal) at the C-ter...