Brain pacemaker to lift anxiety-like behaviour after acute and long-term stimulation of rats
Deep brain stimulation (DBS) is currently being investigated as a potential therapy for treatment-resistant depression. To date, a promising target for DBS as therapy is the subcallosal cingulate gyrus or medial prefrontal cortex (mPFC), with approximately 60% of patients being characterized as resp...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Student Research Poster |
| Language: | English |
| Published: |
2013
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/95901 http://hdl.handle.net/10220/11308 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Deep brain stimulation (DBS) is currently being investigated as a potential therapy for treatment-resistant depression. To date, a promising target for DBS as therapy is the subcallosal cingulate gyrus or medial prefrontal cortex (mPFC), with approximately 60% of patients being characterized as responders. Despite the encouraging findings, the long-term stimulation (LTS) effects on anxiety-like behaviour have not been extensively investigated. In the present study, we report on the effects of acute and long-term bilateral mPFC DBS tested across different paradigms of anxiety-like behaviours. We hypothesized that LTS would exert its therapeutic effects by altering the dysfunctional neural activity leading to normal functional brain circuits. [3rd Award] |
|---|