Metabolic adaptation to a disruption in oxygen supply during myocardial ischemia and reperfusion is underpinned by temporal and quantitative changes in the cardiac proteome

• Main Authors: Lee, Chuen Neng, Li, Xin, Arslan, Fatih, Ren, Yan, Poh, Kian Keong, Sorokin, Vitaly, de Kleijn, Dominique, Lim, Sai Kiang, Sze, Siu Kwan, Adav, Sunil S.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/95962; http://hdl.handle.net/10220/11298
• Institution: Nanyang Technological University

Despite decades of intensive research, there is still no effective treatment for ischemia/reperfusion (I/R) injury, an important corollary in the treatment of ischemic disease. I/R injury is initiated when the altered biochemistry of cells after ischemia is no longer compatible with oxygenated micro...