Population shift between the open and closed states changes the water permeability of an aquaporin Z mutant

• Main Authors: Xin, Lin, Hélix-Nielsen, Claus, Su, Haibin, Torres, Jaume, Tang, Chuyang Y., Wang, Rong, Fane, Anthony Gordon, Mu, Yuguang
• Other Authors: School of Civil and Environmental Engineering
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/95993; http://hdl.handle.net/10220/10786
• Institution: Nanyang Technological University

Aquaporins are tetrameric transmembrane channels permeable to water and other small solutes. Wild-type (WT) and mutant Aquaporin Z (AqpZ) have been widely studied and multiple factors have been found to affect their water permeability. In this study, molecular dynamics simulations have been performe...