Structural basis of substrate binding specificity revealed by the crystal structures of polyamine receptors SpuD and SpuE from pseudomonas aeruginosa

• Main Authors: Wu, Donghui, Lim, Siew Choo, Dong, Yihu, Wu, Jien, Tao, Fei, Zhou, Lian, Zhang, Lian-Hui, Song, Haiwei
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/96044; http://hdl.handle.net/10220/11426
• Institution: Nanyang Technological University

The type III secretion system (T3SS) of Pseudomonas aeruginosa is a key virulence determinant whose expression is induced by polyamine signals from mammalian host. SpuD and SpuE were postulated to be spermidine-preferential binding proteins, which regulate the polyamine content in this bacterial pat...